I carried the MUCH heavier S&W 645 for 15 years and had a strange, vague pain in my hip and thigh the entire time. Now, I'm carrying the Ruger SR9 (same size, weights and thickness as the P345) and have no problems. The length of the grip sticks out a bit, and so requires me to wear a loose shirt, vest or jacket, but I'm used to that from carrying the full sized 5" S&W. With a good belt and holster (such as a Milt Sparks Summer Special), I'm sure I could carry the P345 comfortably concealed.