Ok, we're talking opinions here, not absolute truth, so what you are getting is my opinion, YMMV
For both hunting and just personal protection in the woods, I would carry .41mag, .45LC, or .44mag. In single action I'd go with either a Blackhawk or a Vaquero, For double action I'd pick a Redhwak.
I've used all three pistols and I love them all. My choice for all around most versatile is .45LC, but I'm a sentimentalist.
If I were going to be hiking in bear country a lot I would probably opt for the .44, though, and load it with the hottest rounds the pistol is capable of firing.
If the pistol is primarily for hunting I would probably go with the .41. The Blackhawk in .41 is extremely accurate and the caliber will easily take down anything in North America, providing you practice and can hit your target. Shot placement is always critical.