I have and shoot 3 different .50 caliber muzzle-loaders, 2 older CVA percussion-cap Hawkens, one with a 28-inch barrel (7½ lbs.) for target shooting and one with a 24-inch barrel (6½ lbs.) for deer hunting and a Traditions "Shenandoah" flint-lock (1:66 twist). All of 'em are very accurate with the following loads.
All of 'em "love" a 47 grain (by volume) load of either Swiss or Goex FFFg black powder for target shooting and my hunting CVA Hawken-Hunter Carbine is just as accurate (3 overlaping shots in the bullseye) using 70 grains of Swiss Black Powder for deer hunting.
This 70 grain load is capable of shooting THROUGH a deer with a shot through the "boiler room" at 80 yards or less (my self-imposed range limit on live game)... so no heavier load is really necessary. Always use the most accurate load when hunting as long as that load is capable of fully penetrating or shooting through the game you're hunting.
What you must do is try various powder loads and choose THE most accurate powder load. I use 3-shot groups to determine the load's accuracy. Of course, with a muzzle-loader, you'll rarely get more than a single shot at game so a 3-shot group is all one needs to determine the "most accurate" load(s).
Try to find a "mentor"... someone who is experienced in shooting traditional muzzle loaders (flintlocks or cap-locks) and willing to give you advice and helpful knowledge.
Beware of those who thinks they "know-it-all". Their advice is often questionable. You should also buy Lyman's Manual on Black Powder Shooting and read it front-to-back TWICE. It will give you excellent and valuable information on black powder shooting.
Good luck and have fun... that's the "name-of-the-game" in muzzle-loader shooting.
Strength & Honor...
Ron T.