I've been using the S&W329, since it came out, for hiking and hunting backup in the west coast mountains, usually loaded with .44 Special "Keith" loads from Buffalo Bore, carried in a crossdraw OWB holster. I had a S&W629 Mountain Gun before that.
When in grizzly country, I could switch to heavier loads, but I tend instead to switch to a S&W629 Hunter with the heaviest Garrett loads. But then, in grizzly country, I'm usually carrying a rifle, too, so it probably doesn't matter.
California is the one exception, where I carry the more easily concealable Glock G29 10mm, loaded hot with Double Tap's 180 gr Gold Dots, or the 200 gr Bearclaw hardcast. It's carried in a crossdraw OWB or a homemade chestpack. I may switch to the Delta Elite, though, as I'm much more comfortable shooting it.
I've also been known to put a .22LR in the pack for plinking and little game, but I'd really rather have my son carry that weight.