By which you mean switching uppers from the .22 to .223? If so, no. The lower is slightly different dimensionally, and the magazine well is shaped so that only the M&P-15-22 magazine will fit. Plus, it is solid where the buffer tube on a real AR would be. No threads, it's one molded piece.
Are you refering to the SIG pistols or the rifles. The pistols can be switched to 9mm, 357SIG, 40 S&W. The SIG 522 rifle however cannot be switched over to shoot 223 like the 556.
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