A slightly different perspective here. It depends. On what "vacation" means. Last year, we took a road trip from Arkansas to Oregon, down the coast to Sacramento, then inland south to crossing over into Arizona and back home again. My permit was good everywhere but Oregon and California. However, besides the scenic aspects of the trip, the B&B's we stayed at, etc., we visited family in Oregon and California, some we had not seen in years. So, I unloaded and locked the guns away in the trunk for the duration in Oregon and California. I did not, however, remove my Tea Party and Gadsden flag bumper stickers and front license plate. Actually, most of the parts of Oregon and California we traveled would paint red rather than blue on a colored map of county level election returns. So I wasn't too worried about the bumper stickers and front license plate. Had I been braver, I could have open carried in Oregon, I suppose, but chose not to.
I considered that a "vacation." But I certainly would not visit a state that doesn't honor my CHL for purposes of just "fun and sun." When we visit family in Ohio, we have two routes we can take to get there, both about the same distance. One goes through Illinois. We don't. We'll take a vacation this year (not visiting family) and you can be sure it will only be to a state that honors my permit.