The Colt Trooper with a Python barrel is known as a "Troop-on" or a "Pooper".
Back in the late 1960's the Vietnam was hot and Colt was putting most of it's effort into weapons for the military.
It was near impossible to buy a Python, but for some strange reason, Python barrels were easy to get.
Several enterprising gunsmiths took new Troopers, which had just been discontinued and were plentiful, and welded up the top strap to match the Python barrel rib.
They tuned the action and gave it a Python quality blue job.
One of the gun magazines printed an article about this, and their orders went through the roof.
To this day, people think they have an early Python but a serial number check shows they have one of these re-barreled Troopers.
About the only way to tell is by a serial check, or by a close look at the top strap, where you can just detect the weld job.
So, while you could have this done, by the time you buy a good Python barrel, and pay a GOOD pistolsmith to weld the frame, fit the barrel, and re-blue it, you're going to be putting quite a bit of money into what's basically a "Frankengun".
Doing this level of work is beyond the average local gunsmith, and is something best left to the higher end custom gunsmiths, who cost big money.
I'd suggest either selling the Trooper, (which are bringing good money now days) or saving the money to buy a real Python.