I would, and have, loaned guns to several family members and friends that I knew could safely handle them.
I've also turned down requests from people (friends and even a family member) who wanted to borrow a gun but who had no basic safety training and refused to go to the range and learn.
I've had good experiences loaning out both guns and things like vehicles. My friends/family return them clean, and in the case of the latter, full of gas. I'm also sure that, if situations were ever reversed, they'd loan me theirs. I've been invited on last minute hunts in other states . . . thankfully someone could loan me a gun, and in a few cases a jacket, hat, and boots as well.
I'm surprised at how many people wouldn't allow a trusted friend to borrow a gun.