Indeed, yes, several times. Usually, when I carefully observed, it turned out to be a fit issue. Too large overall was a relatively easy diagnosis, but less easy is a great fit most places, with one or two spots being too big, such as the lower portion of the grip being too big for my pinkie and ring fingers to contribute enough to gripping the weapon.
Less obvious was the way my trigger finger would tend to drag along part of the frame of Glocks, during the trigger stroke, with my right hand more so than my left.
Some pistols, such as the Kahrs, fit we well in the grip area, but the trigger is positioned such that I must bend my trigger finger j-u-s-t right to get proper placement for a straight-back press. I could shoot a Kahr well only if I paid close attention to that detail, but if I used the same placement/position as either my 1911 pistols or DA revolvers, my shots would be off. Training could
have resolved that, but would it interfere with my performance with my other
duty and carry weapons? With the choice to go all-Kahr, or not carry Kahrs, I
sold or traded the Kahr. There was no level three retention duty holster in
existence that met my employer's specs, so going all-Kahr was not an option.
Certain features will tend to hinder my accuracy, with serrations on the trigger being a big one, unless the pistol is single-action-only.