COL: Cartridge Overall Length
There is enough variation in a box of bullets to get that little bit of variation. You buy a box of bullets and, not only do you have variance from bullet to bullet due to variations in jacket/lead/pressure/etc. but you will also have bullets being mixed from several swage dies. For plated bullets, you have plating inconsistencies along with swaging inconsistencies. Thus, you will find length, ogive, and meplat variations.
Then, you have your own press variations and the speed that you moved the ram. This is followed by a seating stem that doesn't exactly fit the bullet, presses mostly on the meplat, and may not be pushing the bullet exactly straight.
One needs to be very concerned about bullet set-back--generally about 0.100" or more, so you should applying thumb/finger pressure to each bullet to see if you can easily push the bullet deeper--which is a FAIL. Didn't your loading manuals give you some idea about COL variation? Do loading manuals even talk about COL anymore?
Every reloader should look at 0.2gn of powder and 0.005" of space to see the insignificance of each. They can have an effect (for very small case or very small charge weights), but it won't be a dangerous one--not even a +P effect.
For comfort, try measuring the COL of factory rounds.
Factory rifle rounds easily have weight variations of +/- 0.5gn, and often more.