Reloader15 will be the best for all three cartridges. You won't be able to get enough Varget in the cases with the .223 to get the velocities listed by Hodgdon. (At least I haven't with three different lot#'s of Varget). I also haven't seen the accuracy others have claimed. It's still BLC2 or IMR4064 for tops in accuracy in the .308 for me. Ditto the .30/06 with 150gr bullets.
I've gotten outstanding accuracy and velocity with RL15 in the .22-250, and RL15 is superb in the .223 with bullets 55gr and heavier. In the .308, RL15 is simply the best powder i've found. Not suprising as RL15 was developed for the .308 aka 7.62x51.
But, if I had to list the best powder for "most anything centerfire" it would still have to be H4895. It's good in the .223, excellent in the .22-250, and hard to beat in the .308 and .30/06. But then, there is RL15, too.... and to me, its just a bit "more-better"........
The "4831's" are way too slow burning for this class of cartridges.....