Generally speaking, heavy-set individuals do not do well with cross-draw holsters, belt or shoulder, because the reach is too far unless they have especially long arms. You probably would be better off looking at strong-side options.
Next, give some thought to your clothing. Are you always able to wear a coat or other covering garment? Will a loose, baggy look work in your environment or not?
Are you a law enforcement officer, or someone else who is obligated to go in harm’s way, who needs to carry a larger weapon, or only interested in self-protection where a lethal encounter is more likely to be a close-up affair, and perhaps can be avoided?
Your situation should dictate the choice of both a handgun and method of carry.
As a private citizen with no law enforcement responsibilities I sometimes carry a .38 Special snub-nose revolver (very reliable and powerful enough) in a pocket holster, and anything else that’s larger will be close at hand in my residence or vehicle.
