.22 Hornet can be loaded to 3,000 fps with 35 grainers for varmints at close to 200 yrds or down loaded to .22 magnum rimfire specs for table fare.
.308 Win. it has bullet choice out the old wazoo! will shoot up to 180 grainers or down to 125 grainers for moose to white tail /antelope.
any thing that can bite back (bear of the grizzled or polar type) or some thing as large as musk oxen, or a p.o'ed. moose or american bison, deserves,something in the.338 Win Mag caliber class.