"And a ______________."
270, 7-08, 308, 30-06 (your choice) in a Savage bolt action with the Accutrigger.
And there are a bunch of other cartridges in the same league. 25-06, 7x57, 280 Rem. etc. I've got 6x45, 270, 7x57, 300 Savage, 308, 30-06 (x3), 300 Winnie, and 8x57 in modern medium bores and they all work fine. If I was only going to have one medium bore it would be the '06, it will do anything you want in North America, and ammo is available anywhere.
And I hate to admit that I don't even own a Savage, but from the ones I've shot they give you the best chance of getting a great shooting rifle out of the box with a great trigger. You have a chance that a Remington etc. might be more accurate, but the Savages just seem darned consistant.