I don't know if it'd be possible to kill a Blackhawk, but of course that being a single action. I did have a Security Six shoot a bit loose, but it was still going when I sold it, not much end play. The GP100 is MUCH sturdier as is the L frames. I don't know if you could kill the GP100 with hot .357 loads, but at the price of weight.
In defense of that Security Six that got loose, I fed it a pretty steady diet of hot hand loads. Factory is pretty tame stuff. My handloads were pushing 700+ ft lbs. If I'd kept it, I think I'd have just had it tightened up. But, I traded it for a much stronger Blackhawk for outdoor/hunting work, a better platform for what I was using the revolver for, and got a DA .357 later. I still have that .357 which is still tight and have a nice Taurus M66 DA revolver to satisfy the DA spot in my safe along side of a S&W M10, fifties era pinned heavy barrel gun which has has many thousands of .38s of power level from wadcutters to +P fired through it and that M10 is still tight.