Really depends what your goals are. You should always clean it before shooting it the first time, that's just good sense.
Beyond that, alot depends on the rifle and it's intended use. A plinker/ranch/knockabout rifle where you're happy with 2-3moa, break in cleaning regimen probably is a waste of time, although caring for your rifle can't hurt.
If you just got your $3,000 benchrest rifle in, you'd probably want to be pretty meticulous about break in.
Really the difference will be small, but if you are looking at shaving off .1moa here and there, little things like this can help. If you are an average shooter shooting offhand with a socom, you likely would not notice any difference.