I like the 10mm and have been loading it for a number of years. It's great to handload for, as others have stated, AA #7, #9, 800X and Longshot are very good powders for the 10, Blue Dot and Power Pistol are also popular. For AA #9 I prefer to use CCI magnum primers.
I have a G20 and G20 SF, both with aftermarket Lonewolf barrels, plus there's a 6" KKM barrel that speeds things up a bit. By summer time I expect to take delivery of a custom 1911 tactical longslide, it will get carry time at my place and on the trail.
Some things I've learned over the years is to load for the bullet and not for the caliber. It's very easy to load the 10mm to uber velocities, but it's more of a challenge to load for the bullet's sweet spot.
Not an upper end 10mm load, but obviously too fast for this 155gr Gold Dot;
This handloaded 165gr Gold Dot performed poorly out of a 40 S&W carbine, but I observed the same results three separate times in 400 Corbon, a ballistic twin of the 10mm in this bullet weight.
While these bullets were captured in water, Speer #14 confirmed later, redline for the JHPs is set at 1300fps. For those who are buying Underwood ammunition, I would strongly suggest you test that ammunition in your personal 10mm. I've destroyed a number of different JHPs at 10mm velocities.
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All is not lost, this was a 200gr WFNGC test, handloaded Double Tap bullet at DT velocities, 4" of solid cow leg bone, left to right;
I like 180gr Gold Dots for JHP carry, but after seeing poor bullet performance in the 1300s, I load for 1265fps. At this lower velocity, which is actually rather fast, the 180gr Gold Dot pushes a lot of stuff out of the way when a lot of stuff gets in the way.
In 10mm, exceeding a bullet's sweet spot typically results in lower bullet performance and this will remain so until bullets are designed and constructed for 10mm velocities.