Perfectly safe.
I use to do it years ago but got worried about the burning speed of the powder being altered, so I stopped.
Hogwash. The powder gets manufactured somewhere, then gets shipped by truck, boat, or airplane to the ammo plant. <Rumble, Rumble, Rumble>
It then gets put into cases and those cases move down the assembly line to have bullets seated on them. They are then but in boxes, clips, or bandoleers. <Rumble, Rumble, Rumble>
They get sealed in cardboard boxes or spam cans and then get shipped to a warehouse or ammo dump by truck, plane, or boat. <Rumble, Rumble, Rumble>
From a retailer's warehouse, they get shipped to your house by the Brown Truck. <Rumble, Rumble, Rumble>
You load the ammo into a magazine and carry it 8+ hours a day, every day. <Rumble, Rumble, Rumble>
Or, you put it in your truck and drive out to your treestand. <Rumble, Rumble, Rumble>
You finally shoot it without incident.