Handgun in the living room, garage, one on mom and dad's side of the bed, Mossberg 500 in the 'office' and my SIG556 within a few seconds of the bed. I keep all of the 22's unloaded. Not out of the thought that they won't do anything to goblins, but my kids know how to use all of those.
As far as safes, I don't really have any faith in a safe to stop anyone. Turns out, I learned how to pick locks on Dad's gun cabinet (I know, it isn't a safe). Locks only keep honest people honest, and I think safes just kind of call out that you have some valuable stuff all in one nice place. Turns out, if I was going to make a real smash and grab on a house that I knew contained a lot of guns, I would do the following:
Scout house for about a week to get a good idea of times they (and close/nosy neighbors) would be out of the house. Cut phone lines, kill power, and chainsaw my way through the walls to the safe. 4 to 5 man team to haul safe out, with a driver on a cell phone.
I ask any of you to tell me how your safe can beat that. I have insurance to cover the guns (rider on my policy). I don't see a whole lot of purpose to high dollar safes. And any time that people talk about how it is irresponsible not to have one, I think to myself that there is no way to beat a determined criminal other than to shoot them. All safes do is slow them down, and a serious professional criminal is nothing to shake a stick at. Do most of us need to worry about serious criminals? Not likely, unless you have a SIGNIFICANT collection. Turns out, there are easier ways to get guns. Also, most petty criminals <should> know that any crime involving a gun takes them from petty crap to felony.
A no joke vault now... that would work.