My grandfather was born in 1874 in Kansas, and as a young adult in Oklahoma Indian Territory. He was a "sooner', settled with the indians before the territory was opened for settlement. Lost his farm during the land rush. He knew many of the old west lawmen, prpbably didn't have dinner with them but knew them. He delivered mail on horseback at a time when mail carriers had to be armed because of cash in letters. Wish I had his long barrel Colt.
Now, he laughed at Hollywood where the bad guy came to town and takes it over. He said the people got together and killed him, shot front, back or bushwhacked, and buried him. People didn't hive up control of their towns.
Now, bona fides aside, my grandfather said, people hit in the upper body with a .44 or .45 went down on the ground and were out of the fight. No Hollywood grunt and grab the shoulder and keep fighting. A shoulder shot destroyed the shoulder and there was no restorative surgery available then.
Obviously, big bullets worked.