Apparently depends on the age.
The 1901 Sears catalog lists the "New Model Premier" for ".22 short or long cartridges."
The 1939 Stoeger's catalog lists the H&R Premier as "shoots .22 Short, Long, and Long Rifle cartridges."
I need some more catalog reprints to cover the intervening years.
A rimfire cylinder's chambers will likely be bored straight for the heel bullets and will "take" anything that doesn't stick out the front of the cylinder.
But if it has a 20 or 24 inch twist for the 29 grain Short or Long bullet, it will not hit much with a 40 grain LR.
I am sure not Mr Goforth, but I recall an old article describing the .22 S&W Long as the .22 Stevens Long, rifle with a crimp to prevent bullets from backing out from recoil in the early .22-32. That had not been a problem with single shot Stevens rifles.