It's muy bueno for deer and hogs, absolutely.
But I just recently sold off a rifle in .25-06 and eliminated the caliber from my collection. Great caliber, but too similar to others that I'm definitely going to keep (.243, .270, 6.5x55). .25-06 seems to be a perfect jack of all trades / "just-one" rifle, as it covers so many bases. But when you have a lot of rifles, then it just doesn't seem to do ONE thing really well. For long-range varmints or hunting, it's a .243 with unnecessary recoil. For hunting, it's a .270 or 6.5x55 with a little less bullet weight and more barrel burn. So, it had to go as a caliber. If I lived in the plains of New Mexico, Colo., etc., where there are buttloads of prairie pronghorns, which you might shoot at up to 400 yards from a good rest, then the .25-06 is about perfect for that kind of hunting. But I don't.