I once mounted a scope on a .243 Handi-Rifle for a neighbor and sighted it in with 100 grain Winchester ammo at 100 yards, using a rock wall for backstop. The target was mounted on a piece of 1/8" signboard and the wall was about 10 feet back. At the first shot, rock fragments came back through the sign board! I couldn't believe they would come back that far, with force enough to penetrate the signboard and was convinced that the round was quite powerful! Since then, we've killed about 6 deer with the .243. Last year, mine was a 140 lb buck at 200 yards, using Hornady 80 grain GMX solid-copper handloads.
I had taken the .243 Tikka T3 Lite because I had to carry a pop-up blind about a half-mile up a hill for relatives coming to hunt in the rain the next day. A nice carrying rifle. The buck appeared in the old road as I was tying off the blind and stood up to look down the road. Using the blind for cover, retrieved the rifle from about 5 yards back. Standing shot...little finger resting on top of the blind to steady the rifle.