They hit on, two or three times, the "reliable rimfire ignition". If rimfire ignition is so dang reliable, why is almost every cartridge loaded today centerfire?
I also wonder about the ballistics of a 22 Magnum in a 1 1/8 inch barrel. Ballistics charts do no good, since they are for a 22-inch rifle barrel.
They suggest you put a shotshell in "every other CYLINDER"? The gun comes with multiple cylinders? Or did he mean "chamber"? If you do put a shotshell in every other chamber, you end up shooting your assailant with one 40 grain bullet, and 50 grains of #12 lead "dust". That does seem like it would make a less-than-ideal self-defense combination.
I'm not sure why requiring two fingers to pull the trigger is a good thing. It would certainly be safer. Seems like about half the time it would not fire. Having the Glock safety doo-dad on the trigger does make sense, since the trigger is larger than any normal trigger, and the trigger guard is notched away. They need something to prevent you from accidentally shooting it when you're sticking it back in the holster, or in your pocket, which is where it seems to be designed to be carried.
Just looks like a really, REALLY dumb idea.