Yea I knew I'd give up a bit of velocity. When I got the powder it was the only thing on the shelf that would work in all my rifle cartridges. I bought all they had at the time. Accuracy is my primary concern for this load. I also have some H335, but not enough to load all the 75 grain bullets I have.
I have mixed brass, but a lot is Fiochi 223, Frontier 223, Lake City 5.56, Frontier 5.56. All the brass except about 1 mag worth was fired from my rifle.
If it's necessary I'd be willing to weigh every powder charge. For load development, it's not too bad. Once I get a load, I would prefer not to have to, but if necessary it's not a huge chore for the amount of reloading I do. I'd get a powder trickler, which I likely will anyway.
I'll be going through this process for 308 too with the same powder. I have enough large rifle primers I don't mind burning a few for load development.