Not really. Unless you have physical proof such a combination would be catastrophic.
You list credentials claiming to have training and experience in such things. As such you should be aware of actual testing done of over sized bullets NOT causing any particular damage as you claim.
Cavalierly making comments about other's knowledge is indicative of a sophomoric attitude. You are dismissed.
Talk about straw men.
I said tremendous pressure increase. Whether or not that would have catastrpohic results depends on several factors. Doesn't change the fact that firing the wrong ammunition, and particularly ammunition with a bullet diameter larger than the bore was intended for, is a very bad idea. Even using bullets of the correct diameter but with exceedingly long bearing surface or of less malleable construction (all copper bullets, brass solids) with load data for normal cup & core bullets of the same weight can cause unsafe pressures.
For the record, though:
Probably the greatest damage would be to dimensions of chamber and need for rebarreling
Would qualify as catastrophic. Metallugically speaking, the difference between a stretched chamber and a blown up gun is pretty much luck. The yield strength of tempered 4140 steel is just 15% below the ultimate tensile strength. Yield is where permanent deformation occurs, ultimate is where it flat out breaks. And if your barrel is 416 stainless, it only has half the strength of a 4140 barrel to begin with.
Of course, the chamber letting go is only one possible scenario. The other is bolt lugs shearing off and sending the bolt through your face.
These failures can and do happen with overpressure conditions, including bore obstructions, detonations, overcharges, wrong powder and incorrect ammunition.
I also never speculated about your knowledge or lack therof.
You told us in plain English that you were unaware of the differences in base-to-shoulder dimensions of the .270 Win and .280 Rem:
Okay. Not having either, I've never paid attention to that measurement. But it also makes sense.
Only one of us here is playing the ad hom game, sport, and it ain't me.