To the reloader, it's much of a muchness. There are fewer options in .410" bullets vs . 429" and . 452" , but case construction is very similar among the three, and none of them are delicate or fiddly brass. So, from a reloading perspective, not much difference.
From a shooter's perspective, there are obvious differences. Magna offer greater velocity, at the cost of recoil. No magnum is ideal for target shooting accordingly. It offers greater velocity and power, at the cost of greater recoil and more difficulty to master.
From a killing perspective, hunting and defense, there are differences. The magna offer flatter trajectories, so more reach in theory. But again, this comes at the cost of recoil that can diminish accuracy for many. On the other hand, people just don't seem to grasp the fact that 325 -300 grs of soft lead at 800 - 850 fps (45 Colt) will kill most anything (the exception being very large heavy boned animals where the hot 44 Mag with solids carries the edge) just as dead as the magna with possibly less recoil and almost certainly less perceived recoil. As to terminal ballistics, with the exception mentioned above of large heavy boned animals where hot, heavy 44 Mag has a clear advantage, all three will likely perform just as effectively given similarly effective shot placement.
I am obviously biased in that I have more firearms chambered in 45 Colt than in any others with the same cartridge, currently have none chambered in 44 Magnum, and have never had any chambered in 41 Magnum.