Not really...
The thumb safety on my 1911 and the decock lever on my H&K USP45F force me to "ride" the safety/lever w/ my right thumb. This feels fine for the first few rounds, but around the fifty mark it starts to wear, and by the 100 mark a blister starts to form. By the time I finish off 150-200 rounds, my hand is bleeding. I live with this inconvenience because in a fire-fight, I won't be shooting more than 20-35 rounds anyway!
My back-up, Glock 26, doesn't fit well at all, but I didn't buy it to shoot all day at the range with. I bought it to conceal well, and if called on, to dispatch a threat.
Needless to say, I can shoot well with any of my firearms, regardless of "fit."