going by what I currently own
It would be (and often is) my 38 airweight body guard of my officers acp and either the ayoob or police model spyderco.
If cash were no object then the 38 would be the same but the 45 would be changed to a custom with a titanium frame (officers sized) SS commander length top end with stainless internal parts, beavertail grip safty, flat mainspring housing, long trigger burns sear & hammer set, std colt safty but in stainless, lowered ejecton port, stainless throuted barrel, 4lb trigger job, all fit together like a perfect mate slick and smooth and perfectly reliable. wilson mags all around (4)