Depends
If they are close with open sights, I would try a head shot. Close is under 50 yards. Farther out I aim behind the shoulder. Most of my rifles shoot above the front blade so I hold six-oclock.
I've killed deer with Krag, 1903A3, Garand, Jap T44, Swede M38, Arg 1909 Carbine, Arg 1891 Carbines, M1 Carbine, K98, P17, Swiss K31. This year I shot a doe with a 1903A3 with a newer C stock and wide front blade.
All of those rifles were one-shot kills with no lost deer.
Shot a nice 8-point 160 field-dressed buck left-handed out of a tree the day before Thanksgiving with a scoped Ruger #1 7X57. Dead on the spot. 130 yards out. 130 Sierra Gameking on 44gr Varget in a Lapua case. Quartering front shot as he turned away. Bullet jacket was under the skin on the far side behind the shoulder.
Headshots or anything in front of the diaphram. I've noticed pure heart shots tend to run a little but about four inches under the backbone they drop on the spot.
Breaking out the old rifles for some doetags now that the buck is gone. Might go back to the Krag or the Swede M38 next. Wish I had one of those cute Swedish Carbines. Friend of mine is offering to loan me his Jap 7.7.
All this shooting in the last three seasons, so new enough data.