I agree with rcmodel that process is most important for safety. Find a way that will keep you safe, and then do it religiously.
However, I also try to make sure I use powders that will give me obvious indications if they are accidentally double-charged, or if the powder bridges in the powder measure and gives me a light charge.
Trail Boss is unmatched for filling a case to the point that it's easily seen. It also flows well through my Lee Pro Auto Disk measure. Unfortunately it is really only good for light target/plinking loads, which is what I use (a lot of) it for.
For higher velocity rounds, I've found the VihtaVuori series of pistol powders to have the best combination of precise metering, clean burning, low ES/SD numbers, and case-filling ability. The Accurate pistol powders are almost as good, but don't usually fill the case as well.
The other powders I've tried and am currently phasing out of my powder locker are:
Titegroup: Fills the case abysmally, to the point that even double charges can be hard to see
Clays: Bridges too easily in my Lee Pro Auto Disk with the amounts of powder I'll usually use it for
Unique: I've never been able to get it to meter accurately over a long reloading session
HS7: future supplies are doubtful
VV N330: Not usually as available as N320 and N340, and doesn't really do anything that they can't do (the gap between N320 and N340 just isn't that big). I've read that they use a lot of N330 for military 9mm Luger rounds, where it could well be the best choice (and explains why it's more difficult to find).
Just my opinion, and worth every penny you paid for it!