Ok, seeing's how I'm headed up the hill to J&G tomorrow, I've read all your comments, taken everything into account and...
I still have no clue.
I agree with
RonAmok, everyone should have at least one center fire revolver in their collection. I'm just not sure this is the time to add one to mine.
And to make matters worse,
J&G has CZ P07's for $430, and that is definitely on my "To-Buy" list. $430 is outside of my current budget, but I could put the difference on a credit card, it's just a question of whether I want to sleep on the couch for a while after my wife goes through the receipts.
My wife has shot both my CZ75 and her Dad's old K22, so I think she'd be ok with either, and for more, ah,
robust home defense, I have
a Mossberg upstairs for that. This will be the pistol that I'll hopefully never have to use to fight my way up to that scattergun.
I think it'll come down to which seems to fit my hand better and which I want more. As I said, they're two excellent guns, I don't think either will be a bad gun for what I want it for. Thanks for your help, everyone, and I'll post some pics of whatever I get later on.