Thanks guys; I was told by the folks in Smyrna you couldn't do a 20 upper on a 21 lower; didn't sound right to me. Thanks, TF
Actually, this kinda makes sense. First off, you would think that they are both identical in every way, as did I. However, owning both a G21 and G20, it seems that Smyrna might be correct. The reason they would say that the complete G21 upper would work on the G20 lower, but not vice versa, is probably due to the very weak plastic pieces on the frame that the recoil guide rod pushes against.
I've used .40 Super and .460 Rowland, utilizing the extremely stiff EFK Firedragon RSA on the G21 frame, and it broke that weak plastic and the slidelock lever. Looking at those pieces in contrast/comparison to the G20, the G20 appears to be THICKER at those spots. As with the thicker frame on the G20, this is more than likely due to the engineering/building for the much higher pressures of the 10mm (esp. Full House loads).
So, perhaps the stronger built G20 can handle the "typical", weaker .45acp wear and tear, but the same might not be possible the other way around. Now, I am sure you can do it, for a while... But, for how long? Mine lasted about 300 or so rounds of .40 Super, .460 Rowland, .45acp.