Remington and interarms ran 1:14, so MAYBE a 50 gr tsx? Haven't tried it, just left them to varmint bullets, but dad lost his only lost deer on too far of a shot with a 55 gr sp, knocked him down, but didn't stay down, my kid's savage has a 1:12 and it's 1.5 moa with the 62 gr scirocco 2s. Terminal performance has been phenomenal, I wanted to REALLY test it 2.5 years ago on a fat pronghorn doe and at 75 yards, hit just into the muscle behind the upper front leg, .22 in and out, but the entrance into the chest was palm sized! Jellied the heart and half a lung, and exited about .35- .44 cal hole(didn't measure) straight through the other side, no recovered bullet and she dropped straight down, death kicked a circle for about 1.5 minutes and then it was knife work. So I'm in the camp of: with the right bullet, it's an amazing choice for deer sized game.