I guess you could say the same thing about a 22-250 vs a .223
Actually I think the .22-250 shoots flatter and faster making it easier to hit targets at longer distances. Some say it hits harder at longer ranges but I'm no expert on that. I don't think there's a lot of difference from what I've read. I do know that I can hit what I shoot at with my .223 out to at least 500 yards unless the wind is too strong. And from what I've seen I don't think the Hornet has the downrange power of a .223.
BTW Vern I would certainly want to use something more powerful than a .22 for a shot that far on a feral dog. A .22 loses a lot of power by the time it gets out to 100 yards. I don't like to shoot anything unless I'm pretty sure it's going to die quickly and that may not happen at 100 yards with a .22. I'd want to use my .223 for that. A Hornet would work I suppose but that still doesn't set it apart from a .223 enough to make it worth the extra money for the ammo IMO. If I was reloading it might not be as much of a problem. I really don't like shooting dogs at that distance anyway. There's too much chance of not hitting it cleanly and I have a thing for dogs even if they are wild. The one time I ever shot a dog with a larger caliber than a .22 it was a bad situation. The dog didn't die until I tracked it down and shot it again. And I had shot it solidly the first time. It took hours to track it down. I don't ever want to go through that again. If I shoot a dog I want a clean hit right behind the ear where I know the dog is going to die instantly or within a few seconds at most. I'm not the same on shooting varmints but I would want to shoot a game animal where I knew it would die too. I still haven't figured out how that dog managed to live after I shot it the first time but it did. It was a bad situation.