FWIW: The worst shot-up deer I've ever seen was the first one I ever saw dead but on the hoof.
It was shot with a 220gr Remington Cor-lokt factory load circa 1969.
The deer was shot with the classic "Texas heart shot". Bullet impacted the left hind leg breaking the femur, transiting the intestines, and broke the right humerous (rt front leg bone) before exiting. The guts were jello and field dressed deer stunk to high heavens. Later, shooter claimed that he got the back straps, right hind leg and left front leg, rest was discarded by the processor as unedible.... (blood shot..).
The Hornady, Nosler, and Sierra's aren't as "soft" as the CoreLokts. Shouldn't be quite as bad... But, for me, I'd sooner use a 210gr cast bullet at nearly same speed before using up the jacketed ones.
But, use what you got !