I (Almost) Always Use CBs or Subsonics and a Target Turret Scope
All you have to do is know the distance, then dial it in. Simple as that. I generally can keep 2" groups off the bench with sub-sonic, target rounds in a match-grade rifle at 225 yards. But, in all seriousness, over the summer I would typically fire around 500 rounds per day. Practice makes "nearly" perfect, but not quite.
The .22LR is my all-time favorite round. There simply is no better, IMHO for medium range varmint with an ultra accurate rifle or pistol, i.e. Kimber, Ruger 10/22 HB, Contender, etc.
Try the heavy .22LR, 60 grain "Sniper" rounds "Aguila" some time. I found them disappointing in my firearms, but others claim they are awesome. Check out the Tracer .22LR some rainy day just for kicks, especially near (15 Mins. before sunset).
I also like Remington Thunderbolts, and Remington Blue Target loads.
Doc2005