Can't believe nobody commented on this. "85 grain and up" isn't exactly correct. You really have to know the rifling twist rate. My Savage 110 (and I believe most rifles in .243) are 1:10. A 1:10 twist rate will not stabilize the 107 grn VLD type bullets; they're too long. So it would be more accurate (no pun intended) to say 85-100 grn.
Regarding ammo, I'm surprised to hear so much praise for the plain jane Remington and Winchester cup and core ammo. Ammo is the cheapest part of any hunt, why skimp there? And, tbh, I've done it, and regretted it. I've taken 4 caribou, ranging in the 200-300 lb class at ranges from 104-312 yards. The only one that wasn't DRT was with Remington core lokt.
My go-to now is the 85 grn Barnes TSX copper solid over a max load of Superperfomance powder. That gets me an avg MV of 3185 fps and a shot groups running about 3/4 moa, give or take. With that velocity, I'm still just above 2k fps (minimum terminal velocity for bullet performance) at 425 yards. I shot that load in a 600 yrd prone NRA Mid-Range match in a lot of wind and still managed to keep everything in the aiming black (which, admittedly, is 3 ft at that range.)