I've loaded a lot of .25/06 for a friends rifle. He passed away in '02 and his rifle dissapeared with his daughter......
I also have taken a LOT of deer with the .257Roberts and a few with a .257wby.
Friends rifle (Cooper custom) liked IMR4350 under a 100gr and H4831SC under a 117-120gr bullet.
I like the 115gr Nosler partitions, however; I've had good results with Hornady's 100gr flat-base, as well as both 117gr RN and Boat-tail PtSpt. Sierra's however have universally given best accuracy with excellent game performance. Best terminal performance has been with the 120gr Remington Cor-lokt, however it is no longer available in component form......
Though as one poster mentioned, the slower powders give much higher velocities, don't neccessarily discount the faster powders. A friend loads only one load in his .25/06. He uses the Sierra 120gr BTHP GameKing over 42.0gr of IMR4320. It "only" gets 2,770fps but shoots 1-hole groups from his Interarms MkX Mauser. He's killed very, very many deer with it..... bang-flops.
Can't argue with that! If I was only going to use one bullet, the Sierra 120gr GK would be it......
But, If I was going to load/use a .25/06, I'd start with a 115-120gr bullet over Reloader25. Velocities trend onto what I get from my .257wby at 10-15gr less powder.....