I have shot 30 deer with a custom 28 inch 25-06 with a sierra 100 gr. spitzer flatbase at 3502 chronoed. Every animal was found, where hit, laying on its back with three or four legs wiggling in the air. No bullet was ever recovered even when I hit two deer with one bullet. Did this twice. Closest shot was 40 yards and 65 yards the first time I got two mule deer with one bullet. Blew the far shoulder out of both animals. Farthest was 660 yards on four point muley and his legs wiggled in the air like the rest. I loaded 243s for friends with 85/87 gr. heads and they had one shot kills out to 300 + yards. Some of these deer ran some. The deer over 300 yds some times needed two shots and ran some. My friends did not want 100 gr. heads as factory 100 gr. failed them. I shoot the same load at varmits. This keeps my deer hunting eye sharp. The 25-06 is fun to shoot. I like it alot. I hope this field data helps you. Have fun and bangaway.