That is what they were made for.
Note, though, that the accelerator round will probably not shoot to the same point of impact as whatever regular round you are using, and might not be as accurate. For example, my .30-'06 Remington 700 was and is sighted dead on at 100 yds with 150 grain bullets. But accelerators shot about 8 inches high and 3 inches to the left with a 2" group. I chose to forget them rather than resight the rifle, but then I have a .22-250 for varmint use that is a lot more accurate than the accelerators.
At the time they came out, there was talk of sabots being made available for reloaders, and a few companies made them, but I have not seen any for a while. The problem is that to provide the necessary resistance for proper burning of the powder, the factory sabots are heat sealed into the cases, something a reloader is not set up to do (and which could be highly dangerous to try).
For the "one gun" hunter, they do give a degree of flexibility to a "deer rifle" that is not available otherwise even with light bullets.
Jim