The 35 grain V-Max is designed for the .22 Hornet / .218 Bee class of cartridges.
It has a very thin jacket, and no way would it stay together at 22-250 velocities.
The only way it would be at all suitable would be with greatly reduced loads that produced velocity in the 3,000 FPS range or less.
But I have no data on what that reduced load might be.
The 40 grain V-Max is more heavily constructed and can be driven at full velocity in a 1/14 twist 22-250 barrel without blowing up in the air.
You can exceed 4,100 FPS with a MAX load of 40.0 grains Varget.
With all that said, you would be better served with a heavier 50, 55, or 60 grain V-Max in the 22-250. Better long range trajectory, and much better wind bucking ability.
rc