For me, best powders for the.375Ruger are IMR4350, H4350, RL17, and my favorite RL15.
I use 77.0gr of RL15 and the discontinued Hornady 225gr PtSpt. NOT a max load, but minimum that delivers peak accuracy. Runs 3,000fps.
For the Speer 235gr SMP, I use 75.0gr. Gets 2,900fps and tack drives. Moderate recoil. I used it in fall of 2011 to shoot a smallish 10pt buck. Bullet performed just like a 180gr from a .30/06, EXCEPT for the 8ft x 6” divot in the dirt behind the deer!!!! Likely could have killed three deer!
I also use the Sierra 250gr GameKing over the 75.0gr load for 2,900fps. Took it elk hunting in Colorado in ‘13. Elk didn’t cooperate.
81.5gr of the three “4350’s” duplicates factory with a 270gr.
My full power practice load is 81.5gr of IMR4350 under some ancient 270gr Hornady RN I bought for 1970 retail. 5 50rd boxes. $9.99/50.
I also managed some Hornady 270gr PTSPT Interlock blems. $24.00/100. The 250gr Sierras were the deal, Plastic bag of 250 for $27.00! My near lifetime supply of .375’s were less than $125.00 Retail would have been closer to $600. Got them on clearance or bargain bins at various gun shops...
Did something similar for my .260Rem circa 2012 before the current surge of .264”/6.5mm popularity.
True to the “legend”, all the loads in my .375 shoot within 1.25” of same POI at 100yds. The 225’s shoot about 1.25” higher than the 270RN. A Mixed group o 225,235, 250, and 270’s would shoot a 2” tall x1”wide group at 100yds.
It also shoots good with a Lee 255gr FNC over 16.0gr of Unique! But 10” low at 50yds...