A number of articles have been written on the .375 Ruger in "Handloader Magazine". It's an easy cartridge to load for.
With the 200-250gr bullets, RL15 is your powder. Good in the 270 for slightly reduced loads.
With 270-300, it's H4350 (though RL17 should do equally well).
Check in on the Ruger web sites for better responses.
For deer loads, 225gr Hornady and 77.0gr RL15. Accuracy not max at 3,000fps. Ditto 235 gr Speer.
250gr Sierra, 75.0gr RL15, 2,800fps. Sub MOA accurate.
270gr Hornady 72.5 RL15, nice shooter load, 83.0gr H4350, factory published load duplicate 2,800fps.
300gr Nosler 80.0H4350, anything in N. America load. (Most of Africa too, or 300fmj, for everything else.)
BTW, my rifle is a Ruger M77 "African". I'm told it's been to Africa and took numerous plains game including a Cape buffalo.