The most important thing to remember when hunting with a scoped handgun - all of the wobble you see at high magnification is there, and even worse, even when you're NOT shooting high magnification. Don't let yourself get distracted, you'll be fine.
I love 2-6x and 2-8x scopes on 44mag revolvers. When supported, I can crank up to 6-8x and enjoy a great target picture, when firing off hand, I hang out down 2-4x. I'm still waiting for Leupold to re-release the silver VX-3i 2-8x handgun scope, as I'm a big fan of the old VX-3 version. When I hunt with a 44mag, any deer within 150yrds is at risk, and my eyes already aren't what they used to be, so the scope is my sighting option of choice. I don't buy the "can't shoot fast with a handgun scope" excuse - that's a practice issue, not anything to do with the equipment. A guy has to line up their eye, rear sight, front sight, and target when shooting irons. When shooting a red dot or a scope, the shooter has to line up the eye, reticle, and target. When practiced, snap shooting with a scoped revolver can still be quite fast, and the only difference is the discontinuous field of view due to the magnification. I grew up shooting bunnies on the run with a Leup M8 2x on a Mark II. If a guy really wants to hit movers, the open red dot is the best option - continuous FOV (no magnification), minimal obstruction, and only 3 points in space to line up - not 4. Otherwise, a guy just needs to practice his grip with his scoped revolver.
My second favorite is an open type red dot. It's less common to wash out a tube type, but I'm pragmatic about it in the sense if I'm using an optic as large as an Ultradot Match Dot, it's not much more size to add a Leup VX-3 instead, which is more versatile. Alternatively, an RMR or FFIII is nice and compact and can mount in place of the rear sight. I had a Match Dot on one of my SBH Hunter's for a time, but swapped it out eventually for an FFIII. It doesn't offer the same larger FOV, nor the same eye pleasing feedback for concentricity, but the open dots work very well.
Irons have their place. When it comes to a 44mag hunting revolver, for me, that "place" is in my parts drawer. I CAN hunt with irons out to 100yrds, and HAVE done it, but I don't LIKE doing it, and I certainly can't do it as well as I do with a scope or red dot. Kinda like long division, instead of using a calculator... The front sight on a Ruger revolver is over 15MOA wide for me (or pretty well anyone with a 6' 1" or less wingspan). The red dot in the FFIII I have on one of my SRH's is 3MOA, and the crosshair in the VX3 is 1/4MOA. The FFIII is the fastest, the VX3 is the most precise, and the irons are the cheapest.
If a guy isn't really a handgun hunter, but instead just a guy who owns a revolver and might take an opportunity shot here and there every few years with it, and never stretches his wheels out past 50yrds, then sure - any of the above are fine, and the differences moot. I've done the overwhelming majority of my game hunting with handguns over the last 25yrs, and most years, I don't even take a rifle into the deer woods - this year for whitetails I'll be exclusively using a 357/44 B&D Redhawk and a 44mag Super Blackhawk, one I've been using for nearly 20yrs in itself. I use a field rest to gain some range, in the pursuit of elevating my own personal marksmanship; a Primos trigger stick supporting a Bog Gear PSR head, which have proven to be incredibly fast and adaptable, yet still very stable for field wheelgunning.
