I have five different 45-70's (all rifles) and I reload for them, however I have never used 405 grain bullets and don't plan to. I also have two Encore barrels in 45-70 and the heavier bullets increase the felt recoil, which is not pleasant in a handgun. Most of my 45-70 shooting has been from the two Thompson pistols, but I've done a fair amount of shooting my Sharps single shot rifle. The most recoil comes from a small light weight Ruger #1, but the loads for that particular rifle are somewhat hotter than loads for the Sharps and loads for the two Marlins I have. Most reloading manuals will show three separate loads for 45-70, depending on what kind of rifle you are going to be using. These rifles will certainly kill a deer, or just about anything else that gets in the way. We have one fellow in our town who has successfully taken many African game animals with his 45-70's.