I have had excellent results with the Lee .452-300gr-WFNGC. Mine cast at 315gr w/gascheck and lubed. Alloy is wheelweights. 50/50 alox lube.
I've shot them loaded with up to XXX gr of Alliant#2400 through my Winchester mod94. They chrono 1,560fps from 24" bbl.
This is a top listed load and I wouldn't exceed this load. (Use only in T/C, Win 92 or 94 Rifle, or Ruger Revolvers)
Most manuals list 16.5gr for most revolvers such as S&W's. For rifles and Rugers, most will go as high as 18.5gr.
I expect the above load will run around 1,100fps from a 5.5"bbl Ruger.
Pressures were totally acceptable, but recoil is NOTICEABLE! Pressures are a bit below .44mag pressures, but are still substatial for this cartridge.
I'm using Starline Brass, Win LR primers, and seating to foward cannulure. Seated to lower cannulure, rounds won't chamber due to impingement on the rifling.
Only reason to run this bullet at these speeds is to flatten trajectory. Even at the 1,100fps handgun velocities, they will completely penetrate a 300lb hog, or blackbear. I've also read they will penetrate 500lb+ critters as well, but can't speak to that personnally.
Last batch of the above load I ran, I loaded on a progressive loader and used 19.8gr of #2400 and got approx. 1540fps avg.
Accuracy was excellent at around 3" @ 100yds for 5 shots, with open sighted rifle.
Point of aim was approx 6" higher than 250gr Hornady XTP at same powder charge and velocity.
Work up to this load and use caution.
DON'T SHOOT THIS THROUGH ANY COLT-SAA OR REPLICA !!!