I have personally taken about 10 antelope and 1 mule deer with a .45 Colt. My wife has taken around 6 antelope and 5 mule deer with her .45 Colt. She uses a 4 3/4" Seville and the handload is a 260 Keith cast at 900 fps. This load will shoot lengthwise of antelope and mule deer at 100 yards. In my estimation it kills as well as the .270, 30-06 class rifles if the shots are placed properly. If I were hunting heavier game I’d step up the velocity to 1200 fps and in extreme circumstances, (elk, hogs, bear) go to the 310 gr cast slug. This load, 310 at 1200 will go through elk like so much air. These loads can be managed by anyone who is serious about handgunning big game. My wife is 5' 1" and goes about 100 lbs with her gun on. She likes the power the .45 gives her with a minimum of recoil and blast. She has hunted with me for 15 years now and is a very serious handgun shooter. I think the .45 Colt has a lot to do with this as it gives her big bore power without big bore recoil and blast. My sons also shoot the .45 Colt a lot and I had the pleasure to watch my oldest son, age 14 take a nice mule deer buck this year with a 5 1/2" Colt SAA at about 90 yards range. The load, 260 Keith at 900 fps. Its plain, no bells or whistles, but it works every time.
by John Linebaugh