RCBS powder measures come with two different size drums: one for large cartridges, and the other for small. Are you using the correct size drum? (Don't try to successfully throw small charges while using the larger drum.)
I've never in my life heard of Unique powder being position sensitive; (or prone to detonate) Bulleye, definitely yes, but not Unique; and any charge at or over 6 grains doesn't need oatmeal or kapok over the top of the charge in order to avoid detonation.
Anyway powder detonation problems apply mostly to very small charges of very fast powders and, especially, to intermittent (or first) shots. After the gun recoils you're safe to continue the shot string. Old time reloaders, like me, have the habit of elevating a pistol's muzzle before either taking a shot, or beginning a shot string with Bullseye in the gun.
If you're getting a lot of squibs I suspect that you're being, 'lazy on the press handle'. I always bring the handle to a firm snap at the top of the stroke, and then I let it, more or less, bang down at the bottom of the stroke. Too gentle a hand on the press handle, or not going fully all the way up and down might be contributing to your squib problem.
Don't use older powder that either smells sour, or has a pronounced brownish hue to it. Always remove the powder from the measure after use; and make a nice clean pour every time you fill the measure again. The inside of the powder measure drum and cannister should be kept very clean and dry. On a well used press cleaning out the powder measure is something that's best done several times a year.
Personally I've used many, many pounds of Unique powder without, ever once, experiencing the problem you seem to be having. Neither have I ever been frugal to the point of using small charges of any fast powder. (Yes, Unique - while not as fast as Bullseye - is considered to be a fast powder. Just not dangerously so.)
It has to be either something you're using or doing incorrectly, or it's in your reloading habits. Suggest you pay careful attention to how you raise and lower your press handle. I, also, doubt it's either fresh or properly stored Unique powder that's screwing you up. (You're keeping your powder cool and dry - correct?)
The final thing I can think to tell you is not to make the typical beginner's mistake of trying to move cartridge cases through the press too fast. Slow down, take your time, pay attention to the, 'little details'. Carefully watch what you're doing. Skillful reloading takes time and requires all of your attention - Which (Surprise!) can reward you, over and over again, by taking your mind off any life problems that might have driven you to the reloading bench for a few hour's solace.