As one who likes to hunt more than kill I look at handgun hunting as an exercise in getting to within 50 yards or so for the shot. Open sights and something easliy carried on my hip. With that I prefer a 5 1/2" barrel as maximum and Ruger SA's though I have used my 5" S&W M29 as well. I also need no more than 1000 or 1200 fps to kill whether it be deer, hogs, elk or moose. As the game gets bigger I go to a larger diameter bullet only because I can not because I need to (I am a big bore six, or five, gun junkie). So.... with your question I would use the 480 R but it would be in something other than the Ruger SRH. I load my 475 Linebaugh to less than 480Ruger velocities with 400 gr bulllets, I load my 500 Linebaugh to the same velocities with 450 gr bullets, the 45 Colt with 325's at the same or, if just deer/hogs 280's at 1000 fps, the 44 Mag/Spcls get 300's/250's at 1200 fps or 100o fps... I am sure you get the picture. I have no use for high velocity big bore "hand"guns.